A este nivel se absorben todos los principios inmediatos, gran parte de agua, minerales, iones y vitaminas. Este tipo de diarrea cede con el ayuno. Este tipo de diarrea persiste con el ayuno. El volumen de las heces es, en general, superior a un litro diario. Diarrea infecciosa Las infecciones diarreicas tienen un origen viral, bacteriano o parasitario. Los principales agentes de este tipo de diarrea son E.
|Published (Last):||11 July 2005|
|PDF File Size:||7.95 Mb|
|ePub File Size:||1.13 Mb|
|Price:||Free* [*Free Regsitration Required]|
Correspondence to: A. Abstract Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic disorders. Current treatment of diarrhoea includes replacement of fluid and electrolyte losses using oral rehydration solutions, and drugs targeting intestinal motility or fluid secretion.
Therapeutics in the development pipeline target intestinal ion channels and transporters, regulatory proteins and cell surface receptors. This Review describes pathogenic mechanisms of secretory diarrhoea, current and emerging therapeutics, and the challenges in developing antidiarrhoeal therapeutics. Introduction Diarrhoeal diseases have been a major health problem throughout history. Today, despite the success of interventions such as oral and intravenous rehydration therapy, secretory diarrhoea remains a substantial cause of mortality and morbidity worldwide, particularly in children and the elderly.
The most severely affected regions include developing countries in sub-Saharan Africa and South Asia. Examples include the refugee crisis in Rwanda in , the conflict in Zimbabwe in , and the earthquake in Haiti in Many noninfectious causes of diarrhoea are prominent in developed countries. Diarrhoea is associated with adverse effects of drugs, particularly certain cancer and HIV therapeutics.
The incidence of diarrhoea caused by rota-viruses has fallen dramatically over the past 5 years with the widespread administration of the rotavirus vaccine, although the incidence of diarrhoea caused by noroviruses has increased and become the leading cause of disease outbreaks from contaminated food in the US.
In this Review, we describe the major pathogenic mechanisms of secretory diarrhoea, discuss currently available pharmacological therapies and therapies that are being developed, and examine the major challenges in the development of diarrhoeal therapeutics.
Fluid absorption or secretion involves the coordinated activity of membrane transporters located on the apical lumen-facing and basolateral circulation-facing epithelial membranes.
Functionally, both absorption and secretion can occur in the same epithelial cells, although secretory processes predominate in crypts and absorptive processes in villi.
Enfermedad diarreica aguda e infección gastrointestinal
Secretory diarrhoea: mechanisms and emerging therapies
Diarrea osmótica o secretora: ¿cuál tengo? ¿cómo la trato?