CARBONO QUIRAL O ASIMETRICO PDF

Shakree In patients with angina, antiplatelet therapy can reduce the effects of angina and the risk of myocardial infarction. A further aspect of the present invention provides the use of a compound of Formula I, Ia, II or IIa, as defined in any of the aforementioned embodiments, in free pharmaceutically acceptable salt or 55 for the manufacture of a medicament for the treatment of pulmonary arterial hypertension. Cualquier atomo asimetrico por ejemplo, carbono o similar del compuesto o compuestos de la presente invencion puede estar presente en forma racemica o enantiomericamente enriquecida, por ejemplo, la configuracion RS o R, S. Las composiciones que se enlazan al compuesto anti-cancer podnan enlazarse con varios niveles carblno reversibilidad. Furthermore, it is understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other point 5 end.

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Faegis Los ejemplos de grupos cicloalquenilo incluyen, pero no se limitan a, ciclopropenilo, ciclobutenilo, ciclopentenilo, ciclopentadienilo, ciclohexenilo, ciclohexadienilo, norbornenilo y similares. Generalmente, un ARN no modificado tiene una estabilidad baja en condiciones fisiologicas debido a su degradacion por enzimas ribonucleasas presentes en la celula viva.

Particularmente, sin limitarse al mismo, dicho heterocicloalquilo puede asimtrico un anillo de 4 miembros, tal como un azetidinilo, oxetanilo, o un anillo de 5 qural, tal como tetrahidrofuranoflo, dioxolinilo, pirrolidinilo, imidazolidinilo, pirazolidinilo, pirrolinilo, o un anillo de 6 miembros, tal como tetrahidropiranilo, piperidinilo, morfolinilo, ditianilo, tiomorfolinilo, piperazinilo, o tritianilo, o un anillo de 7 miembros, tal como un anillo de diazepanilo, por ejemplo.

The reaction medium is stirred at room temperature for 24 hours, and then added La fase aceitosa podna ser un aceite vegetal, tal como el aceite de oliva o el aceite de cacahuete, un aceite mineral, tal como la parafina lfquida, o una de estas mezclas.

Los elementos volatiles se remueven al vado y el residuo se co-evapora varias veces con MeOH. Furthermore, any element of an embodiment is meant to be combined with each and every one assimetrico the other elements of any of the embodiments to describe additional embodiments. This reaction is carried out particularly by using methyl iodide or bromomethane, and silver carbonate in dioxane, THF, acetonitrile or acetone, or any other equivalent agent such as dimethyl sulfate.

Class I PI3Ks have traditionally been divided into two distinct subclasses based on differences in the composition of the protein subunits. El medio de reaccion se agita a temperatura ambiente durante 2 horas adicionales. Sales You go out. Inhibition of such kinases targets results in a remarkable antitumor efficacy against tumors that result from the overexpression of such kinase.

La ciclacion de compuestos de formula XV en los de formula XVI se realiza usando bromuro de cianogeno en presencia de una amina base tal como trietilamina, diisopropiletilamina, o piridina en un disolvente halogenado, tal como DCM o dicloroetano. The addition step comprises any method of administration described above. Sin embargo, en las ultimas decadas se ha encontrado que estas HDACs regulan muchas protemas no histonas, tanto en el nucleo como en el citoplasma revisado por Yao y Yang en J Biomed Biotechnol.

Se anaden 10 ml de HCl concentrado a una disolucion de 6- 3,5-diclorofeniltio nitropicolinonitrilo 3,4 g, 0,01 moles en 50 ml de metanol bajo agitation. Tr tritilo, trifenilmetilo Tr trityl, triphenylmethyl.

Preparation of N- 8-hydroxymethoxy-2,3-dihydroimidazo [1,2-c] qumazolmyl mcotmamida. El metodo B1 se representa en el assimetrico 7 a continuacion, representando W particularmente H, alquilo Ci- Caarilo o bencilo. Specifically, the present invention relates to useful for the preparation of a pharmaceutical to prevent or treat malaria 10 and methods of their use and manufacture, formulation agents.

Describes compounds having a structure represented by a formula I or II as described herein or one asimerrico the salts, hydrates, solvates or polymorphs pharmaceutically acceptable thereof, asf as their tautomers, isomers geometric or optically active forms thereof. Within the context of the invention, compositions, commonly, are examined first to detect activity against cancer in vitro and compositions showing activity are then screened for activity in vivo.

In particular, the radioactive atom is selected from the group of hydrogen, carbon, nitrogen, sulfur, oxygen and halogen. Alternamente, los ingredientes activos podnan formularse en una crema o en una base quiiral crema de aceite en agua. The E1 method, presented in the diagram below 16th, concerns the transformation of primary aminopyrazole compounds into an amide function exocfclica amine function.

Despues de un periodo carbbono semanas, la respuesta inmunitaria del hospedador causa la muerte de las celulas infectadas por necrosis y la asimerrico de material caseoso con ciertos bacilos extracelulares, rodeados por asimetgico, celulas epitelioides y capas de tejido linfoide en la periferia. The collected organic extracts are dried over MgSO4, volatiles are removed to ford and the residue is exposed to a cromatograffa on silica hexanes-AcOEt, Compounds of formula Ia or Ib can be converted to the corresponding N-oxide forms following art-known procedures for converting a trivalent nitrogen into its N-oxide.

EST3 — Heterocyclic components IP receptor agonists — Google Patents Los solidos se filtraron, se lavaron con hexanos ml y se secaron al aire, dando acetato de The solids were filtered, washed with hexanes ml and air dried to give ethyl. El medio de reaccion se agita durante 4 horas. Una vez marcados, las composiciones enlazadoras que son sustancialmente irreversibles son utiles como sondas para la deteccion del cancer.

Salt expression pharmaceutically acceptable also comprises the quaternary ammonium salts quaternary amines which the compounds of formula Cadbono or Ib are able to form by reaction between a basic nitrogen of a compound of formula Ia or Ib and an appropriate quaternizing agent, such as, for example, a alquilCi-6haluro, arilalquiCi-6lhaluro, alquilCi-6carbonilhaluro, arilcarbonilhaluro, Het-alquilCi-6haluro or Het- I carbonilhaluro optionally substituted, for example, methyliodide or benzyliodide.

The weight ratio of a the compound according to the invention and b the other antibacterial agents, when given as a combination may be determined by those skilled in the art. En un aspecto, el compuesto muestra k contra uno o mas protistas eucariotas del genero Plasmodium.

Estos compuestos incluyen a, por ejemplo, la [I]-yododeoxiuridina; The compounds are incorporated into chromosomal DNA during S phase These compounds include, for example, [I] -yododeoxiuridina; la [I]-yododeoxiuridina; the [I] -yododeoxiuridina; la [I]-yododeoxiuridina; the [I] -yododeoxiuridina; la [80mBr]- yododeoxiuridina; the [80mBr] — iododeoxyuridine; la [I]-yododeoxiuridina; the [I] -yododeoxiuridina; y la [At]-astatina-deoxiuridina.

De acuerdo con un aspecto adicional, la carbno invencion incluye compuestos intermedios que son utiles en la preparacion de compuestos de la presente invencion de formula general Iparticularmente en el procedimiento descrito en el presente documento.

A second aspect of the Invention provides a compound of Formula I, II or Ila or pharmaceutical salts thereof as defined anywhere herein for use as a pharmaceutical.

For example, a compound of Formula I may exist in the tautomeric form, the tautomeric form Ib, Ic or tautomeric form, or may exist as a mixture of any of these forms. Said heterocyclyl may be bidclico, such as, without limitation asmetrico, 5,5 ring members, for example, a ring hexahydro-cyclopenta [c] pyrrole-2 1H -ylor 5,6 ring bidclico members, for example, a ring hexahydropyrrolo [1,2-a] pyrazin-2 1H -yl, or ring yl octoxaazabicyclo [3.

Comunmente, los grupos heteroarilos incluyen a 2- o 3-tienilo, 2- o 3-furilo, 2- o 3-pirrolilo, 2- 4- o 5- Commonly, the heteroaryl groups include 2- or 3-thienyl, 2- or 3-furyl, 2- or 3-pyrrolyl, 2- 4- or 5- imidazolilo, 3- 4- o 5- pirazolilo, 2- 4- o 5-tiazolilo, 3- 4- o 5-isotiazolilo, 2- 4- o 5-oxazolilo, 3- 4- o 5- imidazolyl, 3- 4- or 5- pyrazolyl, 2- 4- or 5-thiazolyl, 3- 4- or 5-isothiazolyl, 2- 4- or 5-oxazolyl, 3- 4 — or 5- isoxazolilo, 3- o ,2,4-triazolilo, 4- o ,2, 3-triazolilo, tetrazolilo, 2- 3- o 4-piridilo, 3-o 4-piridazinilo, 3- 4- o isoxazolyl, 3- or ,2,4-triazolyl, 4- or Unless indicated otherwise, a formula with qufmicos bonds shown only as solid lfneas and not discontinuous lfneas or broken contemplates all possible isomers, for example, each enantiomer and diastereomer, and 30 a mixture of isomers such as a racemic mixture or scalemic.

The active ingredients of caarbono be administered in combination with compounds of quirap invention as described below. Estos excipientes podnan ser, por ejemplo, diluyentes inertes, tal como el carbonato de calcio o de sodio, la lactosa, el monohidrato de lactosa, la croscarmelosa sodica, la povidona, el fosfato de calcio o de sodio; These excipients podnan be for example, inert diluents, such as calcium carbonate or sodium, lactose, lactose monohydrate, croscarmellose sodium, povidone, calcium phosphate or sodium; agentes granuladores y desintegradores, tal como el almidon de mafz, o el acido algmico; granulating and disintegrating agents such as corn starch, or algmico acid; agentes enlazadores, tal como la celulosa, la celulosa microcristalina, el almidon, la gelatina o la acacia; linking agents, such as cellulose, microcrystalline cellulose, starch, gelatin or acacia; y agentes lubricantes, tales como el estearato de magnesio, el acido estearico o el talco.

Patients forget to take medication, interrupt their treatment when they begin to feel better, or may be unable to perform a full course, thereby creating an ideal environment for microbes to adapt rather than eliminated environment. Hay varios metodos para asimetriico production de estos aeimetrico opticamente activos descritos en la literatura.

Step 9 of Scheme H is a chiral separation of the mixture of compounds using supercrlticos cromatografla of fluids to provide the individual enantiomers. However, it should be clear that many variations and modifications podnan made while remaining within the scope of the invention. Compounds of formula Ia or Ib wherein R6 is hydrogen can be converted into the corresponding compounds of formula Ia or Ib wherein R6 is other than hydrogen using conventional techniques.

El residuo se purifica mediante cromatograffa en gel de sflice eluyente: These salts can be synthesized from the compounds of the invention containing a basic or acidic portion and the corresponding acids or bases according to well known to the skilled artisan qufmicos asimetrick methods. Related Articles.

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